Matthew D Layne Selected Research

Carboxypeptidases

1/2021	Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A.
10/2020	Mechanisms of aortic carboxypeptidase-like protein secretion and identification of an intracellularly retained variant associated with Ehlers-Danlos syndrome.
1/2018	Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue.
1/2018	Bi-allelic Alterations in AEBP1 Lead to Defective Collagen Assembly and Connective Tissue Structure Resulting in a Variant of Ehlers-Danlos Syndrome.
1/2014	Aortic carboxypeptidase-like protein (ACLP) enhances lung myofibroblast differentiation through transforming growth factor β receptor-dependent and -independent pathways.
7/2010	Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development of the eviscerated intestine.
3/2009	Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Matthew D Layne Research Topics

Disease

8	Inflammation (Inflammations) 11/2020 - 01/2002
8	Fibrosis (Cirrhosis) 10/2020 - 03/2009
5	Endotoxemia 10/2018 - 07/2003
5	Neointima 11/2014 - 04/2002
4	Vascular System Injuries 01/2021 - 12/2005
4	Atherosclerosis 02/2015 - 05/2002
3	Sepsis (Septicemia) 10/2018 - 10/2003
3	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2011 - 05/2006
2	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 10/2020 - 01/2018
2	Vascular Remodeling 03/2014 - 09/2003
2	Vascular Diseases (Vascular Disease) 08/2012 - 09/2003
2	Critical Illness (Critically Ill) 05/2010 - 02/2009
2	Infarction (Infarctions) 03/2005 - 02/2002
2	Reperfusion Injury 03/2005 - 02/2002
1	Abdominal Aortic Aneurysm 04/2022
1	Breast Neoplasms (Breast Cancer) 02/2022
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2021
1	Pulmonary Atelectasis 11/2020
1	Abdominal Obesity 01/2019
1	Glucocorticoid Receptor Deficiency 01/2019
1	Hyperplasia 01/2018
1	Hypertrophy 01/2018
1	Systemic Scleroderma (Systemic Sclerosis) 01/2015
1	Sclerosis 01/2015
1	Hypertension (High Blood Pressure) 08/2012
1	Lung Diseases (Lung Disease) 06/2012
1	Chronic Obstructive Pulmonary Disease (COPD) 03/2012
1	Gastroschisis 07/2010
1	Acute Lung Injury 05/2010
1	Idiopathic Pulmonary Fibrosis 03/2009
1	Infections 02/2009
1	Myocardial Ischemia (Ischemic Heart Diseases) 03/2005
1	Diabetes Complications 03/2005
1	Hypercholesterolemia 09/2003
1	Emphysema 05/2002
1	Ischemia 02/2002
1	Myocardial Infarction 02/2002

Drug/Important Bio-Agent (IBA)

16	Proteins (Proteins, Gene)FDA Link 04/2022 - 02/2002
7	CarboxypeptidasesIBA 01/2021 - 03/2009
6	CollagenIBA 01/2021 - 03/2009
5	Cysteine (L-Cysteine)FDA Link 04/2022 - 12/2005
5	Heme Oxygenase-1IBA 06/2012 - 01/2002
4	Transcription Factors (Transcription Factor)IBA 01/2015 - 09/2004
4	Nitric Oxide Synthase (NO Synthase)IBA 02/2009 - 10/2003
3	Extracellular Matrix ProteinsIBA 10/2020 - 01/2014
3	EndotoxinsIBA 10/2018 - 07/2003
3	myocardinIBA 01/2015 - 12/2011
2	Heme (Haem)IBA 11/2020 - 06/2012
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2020 - 03/2005
2	LipopolysaccharidesIBA 11/2020 - 10/2003
2	CytokinesIBA 03/2014 - 08/2012
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2014 - 03/2009
2	DNA (Deoxyribonucleic Acid)IBA 05/2010 - 09/2004
2	stallimycinIBA 05/2010 - 09/2004
2	EnzymesIBA 03/2008 - 10/2003
2	Actins (F Actin)IBA 09/2003 - 04/2002
1	Angiotensin IIIBA 04/2022
1	Collagen Type I (Type I Collagen)IBA 02/2022
1	GelsIBA 02/2022
1	InterferonsIBA 11/2020
1	Carrier Proteins (Binding Protein)IBA 10/2020
1	GlucocorticoidsIBA 01/2019
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 10/2018
1	FibrinIBA 10/2018
1	oxidized low density lipoproteinIBA 02/2015
1	perlecanIBA 02/2015
1	NexusIBA 08/2012
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 08/2012
1	SmokeIBA 06/2012
1	Silicon Dioxide (Silica)FDA LinkGeneric 06/2012
1	AsbestosIBA 06/2012
1	Air Pollutants (Pollutants, Air)IBA 06/2012
1	Sp3 Transcription FactorIBA 03/2012
1	Messenger RNA (mRNA)IBA 03/2012
1	P-SelectinIBA 05/2010
1	DiscoidinsIBA 03/2009
1	LigandsIBA 02/2009
1	Telomerase (Telomerase Reverse Transcriptase)IBA 05/2006
1	Blood Glucose (Blood Sugar)IBA 03/2005
1	Protein Isoforms (Isoforms)IBA 10/2003
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2003
1	CholesterolIBA 09/2003
1	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 09/2003
1	Apolipoproteins E (ApoE)IBA 09/2003
1	ApolipoproteinsIBA 09/2003
1	Interleukin-10 (Interleukin 10)IBA 07/2003
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 07/2003
1	cathepsin SIBA 05/2002
1	invariant chain (Ii-Key)IBA 05/2002
1	Interleukin-1beta (Interleukin 1 beta)IBA 02/2002
1	Therapeutic UsesIBA 02/2002

Therapy/Procedure

5	Therapeutics 01/2019 - 02/2002
2	Ligation 11/2014 - 02/2002
1	Thoracotomy 11/2020
1	Tissue Expansion 01/2018